Selected Publications

2022

Freeburg, S.H., Goessling, W., 2022. YAP-deLIVERing the directions and the fuel. Developmental Cell 79, 1004-1017. Pubmed

2021

Kochis, M., Goessling, W., 2021. Learning During and From a Crisis: The Student-Led Development of a COVID-19 Curriculum. Academic Medicine 96, 399-401. Pubmed
Koltowska, K., Okuda, K.S., Gloger, M., Rondon-Galeano, M., Mason, E., Xuan, J., Dudczig, S., Chen, H., Arnold, H., Skoczylas, R., Bower, N., Paterson, S., Lagendijk, A.K., Baillie, G.J., Leshchiner, I., Simons, C., Smith, K.A., Goessling, W., Heath, J.K., Pearson, R.B., Sanji, E., Schulte-Merker, S., Hogan, B.M., 2021. The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function. Nature Cell Biology 23, 1136-1147. Pubmed
Miller, B.M., Oderberg, I.M., Goessling, W., 2021. Hepatic Nervous System in Development, Regeneration, and Disease. Hepatology 74, 3513-3522. Pubmed
Oderberg, I.M., Goessling, W., 2021. Partial Hepatectomy in Adult Zebrafish. Journal of Visualized Experiments 170, 10.3791. Pubmed
Schepers, A.G., Shan, J., Cox, A.G., Huang, A., Evans, H., Walesky, C., Fleming, H.E., Goessling, W., Bhatia, S.N., 2021. Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function. ACS Chemical Biology 16, 1770-1778. Pubmed
Wrighton, P.J.,Shwartz, A., Heo, J., Quenzer, E.D., LaBella, K.A., Harper, J.W., Goessling, W., 2021. Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy. Journal of Cell Science 134, jcs256255. Pubmed

2020

Chaturantabut, S., Shwartz, A., Garnaas, M.K., Labella, K., Chia-Cheng, L., Carroll, K.J., Cutting, C.C., Budrow, N., Palaria, A., Gorelick, D.A., Tremblay, K.D., North, T.E., Goessling, W., 2020. Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development. Hepatology 72, 1786-1799 Pubmed
Demy, L.D., Carrere, M., Noche, R., Tauzin, M., Le Bris, M., Baek, C., Leshchiner, I., Goessling, W., Herbomel, P., 2020. The cationic amino acid exporter Slc7a7 is induced and vital in zebrafish tissue macrophages with sustained efferocytic activity. Journal of Cell Science 133, jcs249037. Pubmed
DiNapoli, S.E., Martinez-McFaline, R., Gribbin, C.K., Wrighton, P.J., Balgobin, C.A., Nelson, I., Leonard, A., Maskin, C.R., Shwartz, A., Quenzer, E.D., Mailhiot, D., Kao, C., McConnell, S.C., de Jong, J.L.O., Goessling, W., Houvras, Y., 2020. Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic Acids Research 48, e38. Pubmed
Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E., 2020. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell 55, 133-149. Pubmed
Freeburg, S.H., Goessling, W., 2020. Hepatobiliary Differentiation: Principles from Embryonic Liver Development. Seminars in Liver Disease 40, 365-372. Pubmed
Goyal, L., Chaudhary, S.P., Kwak, E.L., Abrams, T.A., Carpenter, A.N., Wolpin, B.M., Wadlow, R.C., Allen, J.N., Heist, R., McCleary, N.J., Chan, J.A., Goessling, W., Schrag, D., Ng, K., Enzinger, P.C., Ryan, D.P., Clark, J.W., 2020. A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer. Investigational New Drugs 38, 1533-1539. Pubmed
Lundin V., Sudgen, W.W., Theodore, L.N., Sousa, P.M., Han, A., Chou, S., Wrighton, P.J., Cox, A.G., Ingber, D.E., Goessling, W., Daley, G.Q., North, T.E., 2020. YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental Cell 52, 446-460. Pubmed
Luong, P., Li, Q., Chen, P., Wrighton, P.J., Chang, D., Dwyer, S., Bayer, M., Snapper, S.B., Hansen, S.H., Thiagarajah, J.R., Goessling, W., Lencer, W.I., 2020. A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Molecular Biology of the Cell 31, 511-519. Pubmed
Walesky, C.M., Kolb, K.E., Winston, C.L., Henderson, J., Kruft, B., Fleming, I., Ko, S., Monga, S.P., Mueller, F., Apte, U., Shalek, A.K., Goessling, W., 2020. Functional compensation precedes recovery of tissue mass following acute liver injury. Nature Communications 11, 5785. Pubmed
Weeks, O., Bosse, G.D., Oderberg, I.M., Akle, S. Houvras., Y., Wrighton, P.J., LaBella, K., Iverson, I., Tavakoli, S., Adatto, I., Shwartz, A., Kloosterman, D.,Tsomides, A., Charness, M.E., Peterson, R.T., Steinhauser, M.L., Fazeli, P.K., Goessling, W., 2020. Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. Journal of Clinical Investigation 130, 2252-2269. Pubmed
Zhang, Y., Guillermier, C., De Raedt, T., Cox, A.G., Maertens, O., Yimlamai, D., Lun, M., Whitney, A., Maas, R.L., Goessling, W., Cickowski, K., Steinhauser, M.L., 2020. Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity. iScience 23, 101355. Pubmed

2019

Chambers, B.E., Gerlach, G.F., Clark, E.G., Chen, K.H., Levesque, A.E., Leshchiner, I., Goessling, W., Wingert, R.A., 2019. Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development 146, dev172387. Pubmed
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Acuña, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W., 2019. Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology 156, 1788-1804.e13. Pubmed
Goessling, W., 2019. Position Is Destiny: Metabolism and Cell Identity. Cell Metabolism 29, 1017–1019. Pubmed
Nissim, S., Leshchiner, I., Mancias, J.D., Greenblatt, M.B., Maertens, O., Cassa, C.A., Rosenfeld, J.A., Cox, A.G., Hedgepeth, J., Wücherpfennig, J., Kim, A.J., Henderson, J.E., Gonyo, P., Brandt, A., Lorimer, E., Unger, B., Prokop, J.W., Heidel, J.W.J.R., Wang, X.-X., Ukaegbu, C.I., Getz, G., Sunyaev, S.R., Harper, J.W., Cichowski, K., Kimmelman, A.C., Houvras, Y., Syngal, S., Williams, C., Goessling, W., Wucherpfennig, J.I., Kim, A.J., Henderson, J.E., Gonyo, P., Brandt, A., Lorimer, E., Unger, B., Prokop, J.W., Heidel, J.W.J.R., Wang, X.-X., Ukaegbu, C.I., Jennings, B.C., Paulo, J.A., Gableske, S., Fierke, C.A., Getz, G., Sunyaev, S.R., Wade Harper, J., Cichowski, K., Kimmelman, A.C., Houvras, Y., Syngal, S., Williams, C., Goessling, W., 2019. Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. Nature Genetics 51,1308-1314. Pubmed
Shwartz, A., Goessling, W., Yin, C., 2019. Macrophages in Zebrafish Models of Liver Diseases. Frontiers In Immunology 10, 2840. Pubmed
Wrighton, P.J., Oderberg, I.M., Goessling, W., 2019., There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma. Cellular and Molecular Gastroenterology and Hepatology 8, 347–363. Pubmed

2018

Cox, A.G., Tsomides, A., Yimlamai, D., Hwang, K.L., Miesfeld, J., Galli, G.G., Fowl, B.H., Fort, M., Ma, K.Y., Sullivan, M.R., Hosios, A.M., Snay, E., Yuan, M., Brown, K.K., Lien, E.C., Chhangawala, S., Steinhauser, M.L., Asara, J.M., Houvras, Y., Link, B., Vander Heiden, M.G., Camargo, F.D., Goessling, W., 2018. Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. The EMBO Journal 37, e100294. Pubmed
Haghighi, A., Krier, J.B., Toth-Petroczy, A., Cassa, C.A., Frank, N.Y., Carmichael, N., Fieg, E., Bjonnes, A., Mohanty, A., Briere, L.C., Lincoln, S., Lucia, S., Gupta, V.A., Söylemez, O., Sutti, S., Kooshesh, K., Qiu, H., Fay, C.J., Perroni, V., Valerius, J., Hanna, M., Frank, A., Ouahed, J., Snapper, S.B., Pantazi, A., Chopra, S.S., Leshchiner, I., Stitziel, N.O., Feldweg, A., Mannstadt, M., Loscalzo, J., Sweetser, D.A., Liao, E., Stoler, J.M., Nowak, C.B., Sanchez-Lara, P.A., Klein, O.D., Perry, H., Patsopoulos, N.A., Raychaudhuri, S., Goessling, W., Green, R.C., Seidman, C.E., MacRae, C.A., Sunyaev, S.R., Maas, R.L., Vuzman, D., 2018. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genomic Medicine 3. Pubmed

2017

Kroeger, P.T., Drummond, B.E., Miceli, R., McKernan, M., Gerlach, G.F., Marra, A.N., Fox, A., McCampbell, K.K., Leshchiner, I., Rodriguez-Mari, A., BreMiller, R., Thummel, R., Davidson, A.J., Postlethwait, J., Goessling, W., Wingert, R.A., 2017. The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Developmental Biology 428, 148–163. Pubmed
North, T.E., Goessling, W., 2017. Haematopoietic stem cells show their true colours. Nature Cell Biology 19, 10–12. Pubmed
Walesky, C., Goessling, W., 2017. WNTing no RASt for hepatocellular carcinoma. Hepatology 65, 1435–1437. Pubmed

2016

Cortes, M., Chen, M.J., Stachura, D.L., Liu, S.Y., Kwan, W., Wright, F., Vo, L.T., Theodore, L.N., Esain, V., Frost, I.M., Schlaeger, T.M., Goessling, W., Daley, G.Q., North, T.E., 2016. Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell Reports 17, 458–468. Pubmed
Cox, A.G., Hwang, K.L., Brown, K.K., Evason, K.J., Beltz, S., Tsomides, A., O’Connor, K., Galli, G.G., Yimlamai, D., Chhangawala, S., Yuan, M., Lien, E.C., Wucherpfennig, J., Nissim, S., Minami, A., Cohen, D.E., Camargo, F.D., Asara, J.M., Houvras, Y., Stainier, D.Y.R., Goessling, W., 2016. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nature Cell Biology 18, 886–896. Pubmed
Cox, A.G., Tsomides, A., Kim, A.J., Saunders, D., Hwang, K.L., Evason, K.J., Heidel, J., Brown, K.K., Yuan, M., Lien, E.C., Lee, B.C., Nissim, S., Dickinson, B., Chhangawala, S., Chang, C.J., Asara, J.M., Houvras, Y., Gladyshev, V.N., Goessling, W., 2016. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences 113, E5562–E5571. Pubmed
Goessling, W., North, T.E., 2016. EnaBILEing Growth in the Fetal Liver. Cell Stem Cell 18, 427–428. Pubmed
Goessling, W., Stainier, D.Y., 2016. Endoderm specification and liver development. Methods in Cell Biology. Elsevier Ltd. Pubmed
Kwan, W., Cortes, M., Frost, I., Esain, V., Theodore, L.N., Liu, S.Y., Budrow, N., Goessling, W., North, T.E., 2016. The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell 19, 370–382. Pubmed
Liu, L.Y., Alexa, K., Cortes, M., Schatzman-Bone, S., Kim, A.J., Mukhopadhyay, B., Cinar, R., Kunos, G., North, T.E., Goessling, W., 2016. Cannabinoid receptor signaling regulates liver development and metabolism. Development 143, 609–622. Pubmed
Nissim, S., Weeks, O., Talbot, J.C., Hedgepeth, J.W., Wucherpfennig, J., Schatzman-Bone, S., Swinburne, I., Cortes, M., Alexa, K., Megason, S., North, T.E., Amacher, S.L., Goessling, W., 2016. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Developmental Biology 418, 108–123. Pubmed
Walesky, C., Goessling, W., 2016. Nature and nurture: Environmental toxins and biliary atresia. Hepatology 64, 717–719. Pubmed

2015

Cortes, M., Liu, S.Y., Kwan, W., Alexa, K., Goessling, W., North, T.E., 2015. Accumulation of the Vitamin D precursor cholecalciferol antagonizes hedgehog signaling to impair hemogenic endothelium formation. Stem Cell Reports 5, 471–479. Pubmed
Cox, A.G., Goessling, W., 2015. The lure of zebrafish in liver research: Regulation of hepatic growth in development and regeneration. Current Opinion in Genetics and Development 32, 153–161. Pubmed
Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M.V., Nissim, S., Goessling, W., North, T.E., 2015. Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity. Stem Cells 33, 2596–2612. Pubmed
Goessling, W., Sadler, K.C., 2015. Zebrafish: An Important Tool for Liver Disease Research. Gastroenterology 149, 1361–1377. Pubmed

2014

Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E., 2014. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell 29, 437–453. Pubmed
Cox, A., Goessling, W., 2014. Take the brakes off for liver repair. Nature 506, 299. Pubmed
Goessling, W., North, T.E., 2014. Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Disease Models & Mechanisms 7, 769–776. Pubmed
Nissim, S., Sherwood, R.I., Wucherpfennig, J., Saunders, D., Harris, J.M., Esain, V., Carroll, K.J., Frechette, G.M., Kim, A.J., Hwang, K.L., Cutting, C.C., Elledge, S., North, T.E., Goessling, W., 2014. Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Developmental Cell 28, 423–437. Pubmed

2013

Cox, A.G., Saunders, D.C., Kelsey, P.B., Conway, A.A., Tesmenitsky, Y., Marchini, J.F., Brown, K.K., Stamler, J.S., Colagiovanni, D.B., Rosenthal, G.J., Croce, K.J., North, T.E., Goessling, W., 2014. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Reports 6, 56–69. Pubmed
Cutler, C., Multani, P., Robbins, D., Kim, H.T., Le, T., Hoggatt, J., Pelus, L.M., Desponts, C., Chen, Y. Bin, Rezner, B., Armand, P., Koreth, J., Glotzbecker, B., Ho, V.T., Alyea, E., Isom, M., Kao, G., Armant, M., Silberstein, L., Hu, P., Soiffer, R.J., Scadden, D.T., Ritz, J., Goessling, W., North, T.E., Mendlein, J., Ballen, K., Zon, L.I., Antin, J.H., Shoemaker, D.D., 2013. Prostaglandin-modulated Umbilical cord blood hematopoietic stem cell transplantation. Blood 122, 3074–3081. Pubmed
Harris, J.M., Esain, V., Frechette, G.M., Harris, L.J., Cox, A.G., Cortes, M., Garnaas, M.K., Carroll, K.J., Cutting, C.C., Khan, T., Elks, P.M., Renshaw, S.A., Dickinson, B.C., Chang, C.J., Murphy, M.P., Paw, B.H., Vander Heiden, M.G., Goessling, W., North, T.E., 2013. Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood 121, 2483–2493. Pubmed
Liu, L.Y., Fox, C.S., North, T.E., Goessling, W., 2013. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Disease Models & Mechanisms 6, 1271–1278. Pubmed
Ryan, S., Willer, J., Marjoram, L., Bagwell, J., Mankiewicz, J., Leshchiner, I., Goessling, W., Bagnat, M., Katsanis, N., 2013. Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development (Cambridge) 140, 4445–4451. Pubmed
Shan, J., Schwartz, R.E., Ross, N.T., Logan, D.J., Thomas, D., Duncan, S.A., North, T.E., Goessling, W., Carpenter, A.E., Bhatia, S.N., 2013. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature Chemical Biology 9, 514–520. Pubmed
Yin, J., Zhang, F., Zhang, H., Shen, L., Li, Q., Hu, S., Tian, Q., Bao, Y., Jia, W., Wolpin, B.M., Ng, K., Zhu, A.X., Abrams, T., Enzinger, P.C., McCleary, N.J., Schrag, D., Kwak, E.L., Allen, J.N., Bhargava, P., Chan, J.A., Goessling, W., Blaszkowsky, L.S., Supko, J.G., Elliot, M., Sato, K., Regan, E., Meyerhardt, J.A., Fuchs, C.S., 2013. Multicenter phase II study of tivozanib (AV-951) and everolimus (RAD001) for patients with refractory, metastatic colorectal cancer. The oncologist 18, 377–378. Pubmed

2012

Garnaas, M.K., Cutting, C.C., Meyers, A., Kelsey, P.B., Harris, J.M., North, T.E., Goessling, W., 2012. Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Developmental Biology 372, 178–189. Pubmed
Goessling, W., 2012. Hepatic stellate cells and cirrhosis: Fishing for cures. Hepatology 56, 1596–1598. Pubmed
Leshchiner, I., Alexa, K., Kelsey, P., Adzhubei, I., Austin-Tse, C.A., Cooney, J.D., Anderson, H., King, M.J., Stottmann, R.W., Garnaas, M.K., Ha, S., Drummond, I.A., Paw, B.H., North, T.E., Beier, D.R., Goessling, W., Sunyaev, S.R., 2012. Mutation mapping and identification by whole-genome sequencing. Genome Research 22, 1541–1548. Pubmed
Rosenbluh, J., Nijhawan, D., Cox, A.G., Li, X., Neal, J.T., Schafer, E.J., Zack, T.I., Wang, X., Tsherniak, A., Schinzel, A.C., Shao, D.D., Schumacher, S.E., Weir, B.A., Vazquez, F., Cowley, G.S., Root, D.E., Mesirov, J.P., Beroukhim, R., Kuo, C.J., Goessling, W., Hahn, W.C., 2012. β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell 151, 1457–1473. Pubmed
Shaik, S., Nucera, C., Inuzuka, H., Gao, D., Garnaas, M., Frechette, G., Harris, L., Wan, L., Fukushima, H., Husain, A., Nose, V., Fadda, G., Sadow, P.M., Goessling, W., North, T., Lawler, J., Wei, W., 2012. SCF β-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. Journal of Experimental Medicine 209, 1289–1307. Pubmed

2011

Goessling, W., Allen, R.S., Guan, X., Jin, P., Uchida, N., Dovey, M., Harris, J.M., Metzger, M.E., Bonifacino, A.C., Stroncek, D., Stegner, J., Armant, M., Schlaeger, T., Tisdale, J.F., Zon, L.I., Donahue, R.E., North, T.E., 2011. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell 8, 445–458. Pubmed
Goessling, W., North, T.E., 2011. Hematopoietic Stem Cell Development: Using the Zebrafish to Identify the Signaling Networks and Physical Forces Regulating Hematopoiesis, Third Edition. ed, Methods in Cell Biology. Elsevier Inc. Pubmed
North, T.E., Goessling, W., 2011. Endoderm Specification, Liver Development, and Regeneration. Methods in Cell Biology 101, 205–223. Pubmed

2010

North, T.E., Babu, I.R., Vedder, L.M., Lord, A.M., Wishnok, J.S., Tannenbaum, S.R., Zon, L.I., Goessling, W., 2010. PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proceedings of the National Academy of Sciences 107, 17315–17320. Pubmed
North, T.E., Goessling, W., 2010. NOTCHing an Arrow at Cord Blood: Translating Stem Cell Knowledge into Clinical Practice. Cell Stem Cell 6, 186–187. Pubmed
Wang, Y., Krivtsov, A. V, Sinha, A.U., North, T.E., Goessling, W., Feng, Z., Zon, L.I., Armstrong, S.A., 2010. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (New York, N.Y.) 327, 1650–1653. Pubmed

2009

Dovey, M., Patton, E.E., Bowman, T., North, T., Goessling, W., Zhou, Y., Zon, L.I., 2009. Topoisomerase II Is Required for Embryonic Development and Liver Regeneration in Zebrafish. Molecular and Cellular Biology 29, 3746–3753. Pubmed
Goessling, W., 2009. Deciphering Hepatocellular Carcinoma: From Bench to Bedside and Back. Gastroenterology 137, 786–788. Pubmed
Goessling, W., North, T.E., Loewer, S., Lord, A.M., Lee, S., Stoick-Cooper, C.L., Weidinger, G., Puder, M., Daley, G.Q., Moon, R.T., Zon, L.I., 2009. Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration. Cell 136, 1136–1147. Pubmed
North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., Zon, L.I., 2009. Hematopoietic Stem Cell Development Is Dependent on Blood Flow. Cell 137, 736–748. Pubmed

2008

Goessling, W., Massaro, J.M., Vasan, R.S., D’Agostino, R.B., Ellison, R.C., Fox, C.S., 2008. Aminotransferase Levels and 20-Year Risk of Metabolic Syndrome, Diabetes, and Cardiovascular Disease. Gastroenterology 135, 1935-1944.e1. Pubmed
Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., Zon, L.I., 2008. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology 320, 161–174. Pubmed
Upadhyay, G., Goessling, W., North, T.E., Xavier, R., Zon, L.I., Yajnik, V., 2008. Molecular association between β-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/β-catenin signaling. Oncogene 27, 5845–5855. Pubmed
White, R.M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C., Bourque, C., Dovey, M., Goessling, W., Burns, C.E., Zon, L.I., 2008. Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis. Cell Stem Cell 2, 183–189. Pubmed

2007

Goessling, W., North, T.E., Zon, L.I., 2007. Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nature Methods 4, 551–553. Pubmed
Goessling, W., North, T.E., Zon, L.I., 2007. New waves of discovery: Modeling cancer in zebrafish. Journal of Clinical Oncology 25, 2473–2479. Pubmed
North, T.E., Goessling, W., Walkley, C.R., Lengerke, C., Kopani, K.R., Lord, A.M., Weber, G.J., Bowman, T. V., Jang, I.H., Grosser, T., Fitzgerald, G.A., Daley, G.Q., Orkin, S.H., Zon, L.I., 2007. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447, 1007–1011. Pubmed

2006

Goessling, W., Mayer, R.J., 2006. Systemic Treatment of Patients Who Have Colorectal Cancer and Inflammatory Bowel Disease. Gastroenterology Clinics of North America 35, 713–727. Pubmed

Selected Publications

2022

Freeburg, S.H., Goessling, W., 2022. YAP-deLIVERing the directions and the fuel. Developmental Cell 79, 1004-1017. Pubmed

2021

Kochis, M., Goessling, W., 2021. Learning During and From a Crisis: The Student-Led Development of a COVID-19 Curriculum. Academic Medicine 96, 399-401. Pubmed

Miller, B.M., Oderberg, I.M., Goessling, W., 2021. Hepatic Nervous System in Development, Regeneration, and Disease. Hepatology 74, 3513-3522. Pubmed

Oderberg, I.M., Goessling, W., 2021. Partial Hepatectomy in Adult Zebrafish. Journal of Visualized Experiments 170, 10.3791. Pubmed

Schepers, A.G., Shan, J., Cox, A.G., Huang, A., Evans, H., Walesky, C., Fleming, H.E., Goessling, W., Bhatia, S.N., 2021. Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function. ACS Chemical Biology 16, 1770-1778. Pubmed

Wrighton, P.J.,Shwartz, A., Heo, J., Quenzer, E.D., LaBella, K.A., Harper, J.W., Goessling, W., 2021. Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy. Journal of Cell Science 134, jcs256255. Pubmed

2020

Demy, L.D., Carrere, M., Noche, R., Tauzin, M., Le Bris, M., Baek, C., Leshchiner, I., Goessling, W., Herbomel, P., 2020. The cationic amino acid exporter Slc7a7 is induced and vital in zebrafish tissue macrophages with sustained efferocytic activity. Journal of Cell Science 133, jcs249037. Pubmed

Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E., 2020. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell 55, 133-149. Pubmed

Freeburg, S.H., Goessling, W., 2020. Hepatobiliary Differentiation: Principles from Embryonic Liver Development. Seminars in Liver Disease 40, 365-372. Pubmed

Walesky, C.M., Kolb, K.E., Winston, C.L., Henderson, J., Kruft, B., Fleming, I., Ko, S., Monga, S.P., Mueller, F., Apte, U., Shalek, A.K., Goessling, W., 2020. Functional compensation precedes recovery of tissue mass following acute liver injury. Nature Communications 11, 5785. Pubmed

Zhang, Y., Guillermier, C., De Raedt, T., Cox, A.G., Maertens, O., Yimlamai, D., Lun, M., Whitney, A., Maas, R.L., Goessling, W., Cickowski, K., Steinhauser, M.L., 2020. Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity. iScience 23, 101355. Pubmed

2019

Chambers, B.E., Gerlach, G.F., Clark, E.G., Chen, K.H., Levesque, A.E., Leshchiner, I., Goessling, W., Wingert, R.A., 2019. Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development 146, dev172387. Pubmed

Goessling, W., 2019. Position Is Destiny: Metabolism and Cell Identity. Cell Metabolism 29, 1017–1019. Pubmed

Shwartz, A., Goessling, W., Yin, C., 2019. Macrophages in Zebrafish Models of Liver Diseases. Frontiers In Immunology 10, 2840. Pubmed

Wrighton, P.J., Oderberg, I.M., Goessling, W., 2019., There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma. Cellular and Molecular Gastroenterology and Hepatology 8, 347–363. Pubmed

2018

2017

North, T.E., Goessling, W., 2017. Haematopoietic stem cells show their true colours. Nature Cell Biology 19, 10–12. Pubmed

Walesky, C., Goessling, W., 2017. WNTing no RASt for hepatocellular carcinoma. Hepatology 65, 1435–1437. Pubmed

2016

Goessling, W., North, T.E., 2016. EnaBILEing Growth in the Fetal Liver. Cell Stem Cell 18, 427–428. Pubmed

Goessling, W., Stainier, D.Y., 2016. Endoderm specification and liver development. Methods in Cell Biology. Elsevier Ltd. Pubmed

Kwan, W., Cortes, M., Frost, I., Esain, V., Theodore, L.N., Liu, S.Y., Budrow, N., Goessling, W., North, T.E., 2016. The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell 19, 370–382. Pubmed

Liu, L.Y., Alexa, K., Cortes, M., Schatzman-Bone, S., Kim, A.J., Mukhopadhyay, B., Cinar, R., Kunos, G., North, T.E., Goessling, W., 2016. Cannabinoid receptor signaling regulates liver development and metabolism. Development 143, 609–622. Pubmed

Walesky, C., Goessling, W., 2016. Nature and nurture: Environmental toxins and biliary atresia. Hepatology 64, 717–719. Pubmed

2015

Cortes, M., Liu, S.Y., Kwan, W., Alexa, K., Goessling, W., North, T.E., 2015. Accumulation of the Vitamin D precursor cholecalciferol antagonizes hedgehog signaling to impair hemogenic endothelium formation. Stem Cell Reports 5, 471–479. Pubmed

Cox, A.G., Goessling, W., 2015. The lure of zebrafish in liver research: Regulation of hepatic growth in development and regeneration. Current Opinion in Genetics and Development 32, 153–161. Pubmed

Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M.V., Nissim, S., Goessling, W., North, T.E., 2015. Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity. Stem Cells 33, 2596–2612. Pubmed

Goessling, W., Sadler, K.C., 2015. Zebrafish: An Important Tool for Liver Disease Research. Gastroenterology 149, 1361–1377. Pubmed

2014

Cox, A., Goessling, W., 2014. Take the brakes off for liver repair. Nature 506, 299. Pubmed

Goessling, W., North, T.E., 2014. Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Disease Models & Mechanisms 7, 769–776. Pubmed

2013

Liu, L.Y., Fox, C.S., North, T.E., Goessling, W., 2013. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Disease Models & Mechanisms 6, 1271–1278. Pubmed

Ryan, S., Willer, J., Marjoram, L., Bagwell, J., Mankiewicz, J., Leshchiner, I., Goessling, W., Bagnat, M., Katsanis, N., 2013. Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development (Cambridge) 140, 4445–4451. Pubmed

Shan, J., Schwartz, R.E., Ross, N.T., Logan, D.J., Thomas, D., Duncan, S.A., North, T.E., Goessling, W., Carpenter, A.E., Bhatia, S.N., 2013. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature Chemical Biology 9, 514–520. Pubmed

2012

Garnaas, M.K., Cutting, C.C., Meyers, A., Kelsey, P.B., Harris, J.M., North, T.E., Goessling, W., 2012. Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Developmental Biology 372, 178–189. Pubmed

Goessling, W., 2012. Hepatic stellate cells and cirrhosis: Fishing for cures. Hepatology 56, 1596–1598. Pubmed

2011

Goessling, W., North, T.E., 2011. Hematopoietic Stem Cell Development: Using the Zebrafish to Identify the Signaling Networks and Physical Forces Regulating Hematopoiesis, Third Edition. ed, Methods in Cell Biology. Elsevier Inc. Pubmed

North, T.E., Goessling, W., 2011. Endoderm Specification, Liver Development, and Regeneration. Methods in Cell Biology 101, 205–223. Pubmed

2010

North, T.E., Goessling, W., 2010. NOTCHing an Arrow at Cord Blood: Translating Stem Cell Knowledge into Clinical Practice. Cell Stem Cell 6, 186–187. Pubmed

Wang, Y., Krivtsov, A. V, Sinha, A.U., North, T.E., Goessling, W., Feng, Z., Zon, L.I., Armstrong, S.A., 2010. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (New York, N.Y.) 327, 1650–1653. Pubmed

2009

Dovey, M., Patton, E.E., Bowman, T., North, T., Goessling, W., Zhou, Y., Zon, L.I., 2009. Topoisomerase II Is Required for Embryonic Development and Liver Regeneration in Zebrafish. Molecular and Cellular Biology 29, 3746–3753. Pubmed

Goessling, W., 2009. Deciphering Hepatocellular Carcinoma: From Bench to Bedside and Back. Gastroenterology 137, 786–788. Pubmed

Goessling, W., North, T.E., Loewer, S., Lord, A.M., Lee, S., Stoick-Cooper, C.L., Weidinger, G., Puder, M., Daley, G.Q., Moon, R.T., Zon, L.I., 2009. Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration. Cell 136, 1136–1147. Pubmed

North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., Zon, L.I., 2009. Hematopoietic Stem Cell Development Is Dependent on Blood Flow. Cell 137, 736–748. Pubmed

2008

Goessling, W., Massaro, J.M., Vasan, R.S., D’Agostino, R.B., Ellison, R.C., Fox, C.S., 2008. Aminotransferase Levels and 20-Year Risk of Metabolic Syndrome, Diabetes, and Cardiovascular Disease. Gastroenterology 135, 1935-1944.e1. Pubmed

Upadhyay, G., Goessling, W., North, T.E., Xavier, R., Zon, L.I., Yajnik, V., 2008. Molecular association between β-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/β-catenin signaling. Oncogene 27, 5845–5855. Pubmed

White, R.M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C., Bourque, C., Dovey, M., Goessling, W., Burns, C.E., Zon, L.I., 2008. Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis. Cell Stem Cell 2, 183–189. Pubmed

2007

Goessling, W., North, T.E., Zon, L.I., 2007. Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nature Methods 4, 551–553. Pubmed

Goessling, W., North, T.E., Zon, L.I., 2007. New waves of discovery: Modeling cancer in zebrafish. Journal of Clinical Oncology 25, 2473–2479. Pubmed

2006

Goessling, W., Mayer, R.J., 2006. Systemic Treatment of Patients Who Have Colorectal Cancer and Inflammatory Bowel Disease. Gastroenterology Clinics of North America 35, 713–727. Pubmed